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Gene Expression Literature Summary
Assay
Age
Immunohistochemistry (section)
Embryonic, DPC unknown

9 matching records from 9 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Nkx2-1  NK2 homeobox 1   (Synonyms: T/EBP, thyroid-specific enhancer-binding protein, thyroid transcription factor-1, tinman, Titf1, Ttf-1)
Results  Reference
1*J:260471 Gerhardt B, Leesman L, Burra K, Snowball J, Rosenzweig R, Guzman N, Ambalavanan M, Sinner D, Notum attenuates Wnt/beta-catenin signaling to promote tracheal cartilage patterning. Dev Biol. 2018 Apr 1;436(1):14-27
1J:153098 Goss AM, Tian Y, Tsukiyama T, Cohen ED, Zhou D, Lu MM, Yamaguchi TP, Morrisey EE, Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell. 2009 Aug;17(2):290-8
1J:98811 Inanlou MR, Kablar B, Contractile activity of skeletal musculature involved in breathing is essential for normal lung cell differentiation, as revealed in Myf5-/-:MyoD-/- embryos. Dev Dyn. 2005 Apr 20;233(3):772-782
1J:100052 Inanlou MR, Kablar B, Abnormal development of the diaphragm in mdx:MyoD-/-(9th) embryos leads to pulmonary hypoplasia. Int J Dev Biol. 2003 Jun;47(5):363-71
1J:224337 Jia Z, Guo Y, Tang Y, Xu Q, Li B, Wu Q, Regulation of the protocadherin Celsr3 gene and its role in globus pallidus development and connectivity. Mol Cell Biol. 2014 Oct;34(20):3895-910
1J:327969 Khattar D, Fernandes S, Snowball J, Guo M, Gillen MC, Jain SS, Sinner D, Zacharias W, Swarr DT, PI3K signaling specifies proximal-distal fate by driving a developmental gene regulatory network in SOX9+ mouse lung progenitors. Elife. 2022 Aug 17;11:e67954
1J:254523 Magno L, Barry C, Schmidt-Hieber C, Theodotou P, Hausser M, Kessaris N, NKX2-1 Is Required in the Embryonic Septum for Cholinergic System Development, Learning, and Memory. Cell Rep. 2017 Aug 15;20(7):1572-1584
1J:171513 Tian Y, Zhang Y, Hurd L, Hannenhalli S, Liu F, Lu MM, Morrisey EE, Regulation of lung endoderm progenitor cell behavior by miR302/367. Development. 2011 Apr;138(7):1235-45
1*J:35560 Zhou L, Lim L, Costa RH, Whitsett JA, Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung. J Histochem Cytochem. 1996 Oct;44(10):1183-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory